We are a Hispanic themed supermarket chain in California and Nevada. Currently I monitor and maintain 28 store locations, 3 manufacturing / packing plants and 2 warehouses - 1600 nodes in Spiceworks (and growing).
I have a central Spiceworks installation and a installation onsite at all locations in remote mode. Having a running inventory from Spice has been a real value when our store level zombies think they have gotten away with something, I have a means of quickly seeing the new install and can correct the problem.
Our POS is currently ISS45, LOC software (SMS) and doing our first install of NCR ACR-IR in just two weeks.
ISS45 is very stable. Limited in what it will run on and the data that can be imported and exported but it does work well.
LOC SMS has been a mix of good and bad. It will run on almost any PC platform but that is also part of the problem - The developers do not develop on POS hardware and there is also a language gap with the Canadian French support... Our former programmer loved tinkering with it which also cuts into the bad when he thought no one would fire him no matter how bad he behaved. Including not turning over his code base or support software to update his customizations.
ACS-IR is looking VERY good and we are looking forward to the go-live!