Select the EdgeUI key in the left pane and create two new DWORD values in the right pane of Registry Editor.
DisableTLcorner - stands for "Disable Top-Left corner". Set it to 1, and Switcher will not appear when you move your mouse to the top-left corner of the screen. Note that it will still appear if you move the pointer to the bottom-left corner and then move it upwards along the left edge of the screen.
DisableCharmsHint - Set it to 1 to disable the Charms bar when using the mouse. It will not appear when you move the pointer to the top-right or bottom-rights corners. But as above, if you move the pointer to the top-right corner and then move it down along the right edge of the screen (or from the bottom-right corner up to the screen centre along the right edge), it'll appear again.
So, both settings prevent the Edge UI panels from appearing accidentally. They will take effect immediately - you do not need to restart Windows Explorer or log off. You will still be able to show them when you actually want to use them.